A novel engineered VEGF blocker with an

excellent pharmacokinetic profile and robust

anti-tumor activity

Lily Liu1, Haijia Yu1, Xin Huang2, Hongzhi Tan3, Song Li2, Yan Luo1, Li Zhang3, Sumei Jiang3, Huifeng Jia3,Yao Xiong3, Ruliang Zhang4, Yi Huang3, Charles C Chu5,6,7 and Wenzhi Tian1*

Liu et al. BMC Cancer (2015) 15:170

DOI 10.1186/s12885-015-1140-1

.....This designed D2 expression cassette sequence was synthesized (GenScript) and subcloned into the HindIII and EcoRI sites of the pHB-Fc vector (Generay, ID: X9913T).....